Presympto

A Novel Blood Test for Presymptomatic Detection of Alzheimer’s Disease

Alzheimer’s disease (AD) cases continue to increase without effective diagnosis and treatment solutions. Today, there is no successful test to diagnose AD at its earliest stages in healthy asymptomatic individuals to determine disease status. One reason may be the lack of validated biomarkers which prevents a pre-clinical AD diagnosis.   Presympto is developing a novel early detection blood test based on peptide ligands to be used before any signs of AD in healthy asymptomatic individuals to determine their status and risk for AD.

Our technology, Pronucleon™ peptides, utilizes our custom-synthesized peptides that mimic the misfolding region of proteins such as Aβ.  Pronucleon™ peptides:

• Display specificity and sensitivity for Aβ oligomers
• Bind to oligomers on blood cells with higher signal on AD cells
• Exhibit differentiation between healthy and AD samples in our flow cytometry assay

Our initial data sets the stage for an exciting new approach to diagnosing Alzheimer’s disease, allowing the medical community, the AD therapeutic community, and the public an opportunity to address this disease before symptoms appear.

• Simple detection using sequence-specific peptide synthesis
• Ability to detect and screen for the early oligomer form of Aβ
• Deployable at a population screening level
• Capable of detecting pathology in early stage disease 
• Quantitative technology for following progression, or response to therapy
• Additional capability for brain imaging and ophthalmic testing